Borylation directed borylation of -alkyl anilines using iodine activated pyrazaboles.

Doubly electrophilic pyrazabole derivatives (pyrazabole = [HB(μ-CNH)]) combined with one equiv. of base effect the -borylation of -alkyl anilines. Initial studies found that the bis(trifluoromethane)sulfonimide ([NTf]) pyrazabole derivative, [H(NTf)B(μ-CNH)], is highly effective for -borylation, with this process proceeding through N-H borylation and then C-H borylation.

The Impact of a National Cyberattack Affecting Clinical Trials: The Cancer Trials Ireland Experience.

Purpose: Cyberattacks are increasing in health care and cause immediate disruption to patient care, have a lasting impact, and compromise scientific integrity of affected clinical trials. On the May 14, 2021, the Irish health service was the victim of a nationwide ransomware attack. Patient care was disrupted across 4,000 locations, including 18 cancer clinical trials units associated with Cancer Trials Ireland (CTI).

Evolutionary loss of shell pigmentation, pattern, and eye structure in deep-sea snails in the dysphotic zone.

Adaptations to habitats lacking light, such as the reduction or loss of eyes and pigmentation, have fascinated biologists for centuries, yet have rarely been studied in the deep sea, the earth's oldest and largest light-limited habitat. Here, we investigate the evolutionary loss of shell pigmentation, pattern, and eye structure across a family of deep-sea gastropods (Solariellidae). We show that within our phylogenetic framework, loss of these traits evolves without reversal, at different rates (faster for shell traits than eye structure), and over different depth ranges.

Synthesis of Electrophiles Derived from Dimeric Aminoboranes and Assessing Their Utility in the Borylation of π Nucleophiles.

Dimeric aminoboranes, [HBNR] (R = Me or CHCH) containing BN cores, can be activated by I, HNTf (NTf = [N(SOCF)]), or [PhC][B(CF)] to form isolable HB(μ-NR)BHX (for X = I or NTf). For X = [B(CF)] further reactivity, presumably between [HB(μ-NMe)BH][B(CF)] and aminoborane, forms a BN-based monocation containing a three-center two electron B-(μ-H)-B moiety. The structures of HB(μ-NMe)BH(I) and [(μ-NMe)BH(NTf)] indicated a sterically crowded environment around boron, and this leads to the less common O-bound mode of NTf binding.

Borylation Directed Borylation of Indoles Using Pyrazabole Electrophiles: A One-Pot Route to C7-Borylated-Indolines.

Pyrazabole (1) is a readily accessible diboron compound that can be transformed into ditopic electrophiles. In 1 (and derivatives), the B⋅⋅⋅B separation is ca. 3 Å, appropriate for one boron centre bonding to N and one to the C7 of indoles and indolines.