The cerebral blood flow response to neuroactivation is reduced in cognitively normal men with β-amyloid accumulation.

Background: Accumulation of β-amyloid (Aβ) in the brain is a hallmark of Alzheimer's Disease (AD). Cerebral deposition of Aβ initiates deteriorating pathways which eventually can lead to AD. However, the exact mechanisms are not known.

Does sleep quality mediate the association between post-traumatic stress disorder symptom severity and pain interference in trauma-affected refugees?

Poor sleep quality is well recognised in both post-traumatic stress disorder (PTSD) and pain conditions. Comorbid chronic pain is prevalent in populations with PTSD and is believed to maintain symptoms of PTSD and increase the complexity of the condition. Ongoing diminished sleep quality may serve to maintain pain and PTSD symptoms, and thus affect the efficacy of first-line PTSD treatment.

Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis.

Background: Development of anti-drug antibodies (ADAs) and neutralizing antibodies (NAbs) to monoclonal antibodies may adversely impact pharmacokinetics, efficacy, and/or safety.

Objective: To describe incidence, titer, and persistence of dupilumab ADAs and NAbs, and their effects on pharmacokinetics, efficacy, and safety in patients with atopic dermatitis (AD).

Methods: This analysis included seven phase 3 randomized, placebo-controlled (N=2,992) and two long-term open-label extension (N=2,287) trials of subcutaneous dupilumab in adults and pediatric patients with moderate-to-severe AD.

Cognitive aging and reserve factors in the Metropolit 1953 Danish male cohort.

Identifying early predictors of cognitive decline and at-risk individuals is essential for timely intervention and prevention of dementia. This study aimed to detect neurobiological changes and factors related to cognitive performance in the Metropolit 1953 Danish male birth cohort. We analyzed data from 582 participants, aged 57-68 years, using machine learning techniques to group cognitive trajectories into four clusters differentiating high- and low-performing groups.

Differences in Associations of Three Types of Alcoholic Beverages with Age-Related Cognitive Decline in Men.

Objectives: To investigate the influence of wine, beer, and spirits consumption, respectively, on non-pathological, age-related cognitive decline from young adulthood to late midlife in a large follow-up study of Danish men.

Methods: The study includes 2456 middle-aged Danish men from the Lifestyle and Cognition Follow-up study 2015, with information on adult-life consumption (from age 26) of wine, beer, and spirits self-reported in late midlife and age-related cognitive decline assessed using the same validated intelligence test administered in young adulthood and late midlife. Associations were adjusted for consumption of other alcoholic beverages, year of birth, age at follow-up, retest interval, education, young adulthood intelligence, and personality.