Biomarkers.

Background: Aging is linked to significant white matter abnormalities, which are often studied using traditional diffusion tensor imaging (DTI) metrics; however, these traditional metrics have limited sensitivity/specificity to neurobiological characteristics. Here, we use fixel-based analysis (FBA) - an approach with more precision in areas of crossing fibers - to study age-related white matter microstructural decline.

Method: This study uses cross-sectional data from the Vanderbilt Memory & Aging Project cohort [n=325, age at baseline: 72.

Developing Topics.

Background: Socioeconomic neighborhood disadvantage has been linked to accelerated biological aging, cognitive decline, and core Alzheimer's disease neuropathology independent of individual-level factors. Our recent work indicates neighborhood disadvantage is also implicated in cerebrovascular changes known to exacerbate the development of AD, including neurovascular and hemodynamic dysfunction. Here, we investigated how neighborhood disadvantage relates to microstructural changes in white matter, a sensitive biomarker for emerging cerebrovascular disease and related neurodegeneration.

Alzheimer's Imaging Consortium.

Background: Aging is linked to significant white matter abnormalities, which are often studied using traditional diffusion tensor imaging (DTI) metrics; however, these traditional metrics have limited sensitivity/specificity to neurobiological characteristics. Here, we use fixel-based analysis (FBA) - an approach with more precision in areas of crossing fibers - to study age-related white matter microstructural decline.

Method: This study uses cross-sectional data from the Vanderbilt Memory & Aging Project cohort [n=325, age at baseline: 72.

The Impact of "Close Margins" in HPV-Associated Oropharyngeal Squamous Cell Carcinoma Treated with TORS.

Objective: Margin distance is a significant prognosticator in oral cavity cancer but its role in HPV-related oropharyngeal squamous cell carcinoma [HPV(+)OPSCC] remains unclear. Here, we investigate the impact of margin distance on locoregional recurrence in HPV(+)OPSCC.

Study Design: This is a retrospective cohort study of surgically treated HPV(+)OPSCC patients.

The inability to predict futility in hemorrhaging trauma patients using 4-hour transfusion volumes and rates.

Background: Blood shortages and utilization stewardship have motivated the trauma community to evaluate futility cutoffs during massive transfusions (MTs). Recent single-center studies have confirmed meaningful survival in ultra-MT (≥20 U) and super-MT (≥50 U), while others advocate for earlier futility cut points. We sought to evaluate whether transfusion volume and intensity cut points could predict 100% mortality in a multicenter analysis.