Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.

Biological ageing can be defined as a gradual loss of homeostasis across various aspects of molecular and cellular function. Mammalian brains consist of thousands of cell types, which may be differentially susceptible or resilient to ageing. Here we present a comprehensive single-cell RNA sequencing dataset containing roughly 1.

The Effect of Cold Spray Applied Before Local Anesthesia on Anxiety and Pain in Coronary Angiography Procedure: A Randomized Controlled Study.

Purpose: Cardiovascular diseases are a leading cause of morbidity and mortality worldwide. Clinically, various techniques are used to diagnose coronary artery diseases. Coronary angiography is considered the gold standard for the diagnosis of coronary artery disease.

Adolescent Hyperparathyroidism: An Updated Contemporary Surgical Experience at a Tertiary Center.

Introduction: Primary hyperparathyroidism (pHPT) in children is uncommon, resulting in a paucity of data describing the disease process in this population. Herein, in an effort to bridge the information gap, we review our experience with pHPT in adolescent patients under 20 y of age at a specialized tertiary referral center.

Methods: A retrospective chart review included all adolescent patients with pHPT, who underwent surgery at our institution between 2004 and 2023.

interspecies dissemination of IncM2-type carrying plasmid.

The gastrointestinal tract is a unique ecological niche with a high abundance of various Enterobacterales in close proximity. This allows the exchange of mobile genetic elements that carry resistance determinants. In the hospital setting, resistant organisms are prevalent and selective antibiotic pressure is high, providing a supportive platform for interspecies dissemination of resistance.

The Risk of Pneumothorax With Intrapleural Urokinase in Children With Parapneumonic Effusion.

Aim: Fibrinolytic therapy is commonly used in children with parapneumonic effusion, to facilitate drainage of the effusions and recovery. However, data regarding complications of this treatment in children are limited. We aimed to determine the incidence of pneumothorax (PNX) associated with intrapleural urokinase.