[Free-radical processes and glutamate metabolism in the brain of newborn rats developed in uteroplacental circulatory insufficiency].

Lipid peroxidation, antioxidant system, nitric oxide and glutamate metabolism were studied in the brain of 2-day-old rats who had developed in the conditions of experimental deficiency of uteropla- cental circulation. It was found that in such rats lipid peroxidation activated while antioxidant defense decreased. Content of L-arginin - substrate of nitric oxide synthesis and concentration of its end metabolites increased evidencing for hyperproduction of NO in homogenates of the brain of experimental animals.

[The role of nitric oxide in fertility disorders in men].

The aim of the study was investigation of NO influence on fertility properties of ejaculate in the diseases of male sex organs. A total of 73 males aged 20-55 years with different sexual disorders were examined. Potentiometric assay for nitrates in ejaculate, size and shape of spermatosoa were studied.

[Nitrogen oxide in the pathogenesis of glaucoma and cataract].

The content of nitrite (final metabolite of nitroradical) was measured in aqueous humor of patients with glaucoma and cataract. The level of NO formation is increased at the initial stage of glaucoma and decreases with the disease progress. A direct correlation between the level of nitrite in aqueous humor and coefficient of easiness of its discharge was detected.