Evolution of SARS-CoV-2 T cell responses as a function of multiple COVID-19 boosters.

The long-term effects of repeated COVID-19 vaccinations on adaptive immunity remain incompletely understood. Here, we conducted a comprehensive three-year longitudinal study examining T cell and antibody responses in 78 vaccinated individuals without reported symptomatic infections. We observed distinct dynamics in Spike-specific humoral and cellular immune responses across multiple vaccine doses.

How low can you go? Antibiotic use in Swedish dogs with gastroenteritis.

Background: Canine gastroenteritis (CGE) is a common cause for seeking veterinary care in companion animal medicine and an area where antibiotics have been reported to be widely used. Therefore, creating relevant benchmarks for antibiotic use in CGE is important when implementing and analyzing antibiotic stewardship interventions. The aim of this paper was to describe the level and temporal trend of systemic antibiotic use for CGE in Sweden between 2020 and 2023.

Plasticity syndromes in wild vertebrates: Patterns and consequences of individual variation in plasticity across multiple behaviours.

Behavioural plasticity is an important mechanism allowing animals to cope with changing environments. Theory has hypothesized the existence of 'plasticity syndromes'-positive correlations in plasticity across multiple behaviours within an individual-affording a generalized ability to respond to environmental change. However, the occurrence of correlated plasticities and their potential fitness consequences in natural populations remain untested.

Hepatitis B Patients' Adherence to Treatment in Relation to Knowledge, Attitudes, and Practices (KAP) in the West Bank, Palestine, 2022-2023.

Hepatitis B is an infectious disease that inflicts high health and economic costs on the healthcare system. Poor adherence to treatment increases that cost. We aimed to assess the levels of knowledge, attitudes and practices (KAP) among patients in the West Bank, Palestine, and identify factors associated with good adherence.

Increased Resistance of the Peripheral Airways in Patients with Unexplained Chronic Cough.

Introduction: Troublesome coughing that persists for more than 8 weeks without evident aetiology or effective therapy is termed unexplained chronic cough (UCC). Using impulse oscillometry (IOS) and spirometry, we assessed the functionalities of the large and small airways, respectively, in patients with UCC and in healthy control subjects.

Methods: On a single occasion, 50 patients with UCC (mean age, 61 years; 82% women) and 23 subjectively healthy controls (mean age, 58.