Publications by authors named "E L Jacobsen"

Introduction: Postoperative cognitive decline (POCD) is a common, but often unrecognized condition after surgery. We evaluate postsurgical cognitive changes in a longitudinal population-based study.

Methods: The study cohort comprises an age-stratified population-based random sample of individuals aged 65+ years from a small-town region of the United States.

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Background: Nasal defects after skin cancer excision can often be healed by second intention in certain circumstances.

Objective: We aim to demonstrate the utility of bovine collagen xenografts in supplementing second-intention healing of a variety of nose surgical defects.

Results: Thirty-nine patients underwent Mohs micrographic surgery of the nasal tip (33%), ala (23%), dorsum (31%), sidewall (10%), and root (3%) with the application of bovine collagen xenograft.

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  • * An analysis of 1,192 participants revealed elevated sACE2 activity following exposure to SARS-CoV-2, especially in children, indicating a significant response regardless of infection status.
  • * The research suggests that increased sACE2 activity could help manage SARS-CoV-2 infections, proposing a more nuanced understanding of immune responses beyond traditional infection classifications.
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  • Accurate diagnosis in psychiatry is challenging, leading to delays in treatment and worse outcomes; identifying biomarkers for emotional reactivity is key.
  • The study evaluated emotional responses of individuals with bipolar disorder (BD), borderline personality disorder (BPD), schizophrenia spectrum disorders (SSD), and healthy controls (HC) in immersive virtual reality (VR) scenarios, measuring self-rated emotions and galvanic skin response (GSR).
  • Results showed that individuals with BD, BPD, and SSD had more negative emotional responses than HC, with BPD and SSD experiencing heightened unpleasantness and stronger physiological responses in specific VR contexts, suggesting VR assessments could enhance diagnosis and treatment strategies.
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A quantitative and predictive understanding of how attractive noncovalent interactions (NCIs) influence functional outcomes is a long-standing goal in mechanistic chemistry. In that context, better comprehension of how substituent effects influence NCI strengths, and the origin of those effects, is still needed. We sought to build a resource capable of elucidating fundamental origins of substituent effects in NCIs and diagnosing NCIs in chemical systems.

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