Publications by authors named "E L Hess"
Background: Acute ischemic lesions seen on brain magnetic resonance imaging (MRI) are associated with poor intracerebral hemorrhage (ICH) outcomes, but drivers for these lesions are unknown. Rapid hemoglobin decrements occur in the initial days after ICH and may impair brain oxygen delivery. We investigated whether acute hemoglobin decrements after ICH are associated with MRI ischemic lesions and poor long-term ICH outcomes.
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- Multiple myeloma (MM) is a type of cancer that starts in plasma cells and is divided into two main genetic subtypes: hyperdiploid and non-hyperdiploid.
- This study used human myeloma cell lines (HMCLs) to investigate protein expression of cell surface markers relevant to MM treatment, finding that some markers were consistently expressed while others showed variation.
- Analysis revealed that some HMCLs closely matched the characteristics of patient-derived samples, highlighting the need for careful selection of cell lines to best model MM for research and therapeutic purposes.
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- Striatal dysfunction is linked to various types of dystonia, such as idiopathic and inherited forms, with the striatum housing different types of GABAergic neurons that control movement.
- Research using a model of DOPA-responsive dystonia (DRD) revealed that dSPNs and iSPNs exhibit distinct molecular changes that contribute to the disorder, highlighting a specific dysregulation in glutamatergic signaling for both neuron types.
- The differences in how these neurons adapt due to dopamine deficiencies suggest potential biochemical targets for therapies, emphasizing that the impact of dopamine loss on movement disorders varies depending on the timing and the specific neuron type affected.
Objective: To evaluate sociodemographic and clinical factors associated with clinical outcomes in patients hospitalized with neuroinfectious diseases at three tertiary care centers in New York City.
Methods: This retrospective cohort study was conducted at three large urban tertiary care centers between January 1, 2010 and December 31, 2017. Poor clinical outcome was defined as length of hospital stay (LOS) ≥2 weeks and/or discharge to a location other than home.
Introduction: Few rural hospital medicine programs include workforce development training that provides social and professional support for interdisciplinary teams. Even fewer include training that creates supportive learning environments that result in higher staff satisfaction, lower burnout, and reduced turnover. The Acute Inpatient Medicine-High Reliability, Learning Environment, and Workforce Development Initiative (AIM-HI) aims to create supportive learning environments in Veterans Health Administration (VA) rural hospital medicine teams.
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