Cell Type Specific Suppression of Hyper-Recombination by Human RAD18 Is Linked to Proliferating Cell Nuclear Antigen K164 Ubiquitination.

RAD18 is a conserved eukaryotic E3 ubiquitin ligase that promotes genome stability through multiple pathways. One of these is gap-filling DNA synthesis at active replication forks and in post-replicative DNA. RAD18 also regulates homologous recombination (HR) repair of DNA breaks; however, the current literature describing the contribution of RAD18 to HR in mammalian systems has not reached a consensus.

Complete genome of sp. strain BB002, isolated and cultivated from a site of periodontal disease.

strain BB002, was isolated from the human oral cavity on its basibiont bacterial host sp. oral taxon 171 strain F0337, related to . As a member of the within the candidate phylum radiation group (CPR), its reduced genome facilitates the survival as an ultrasmall (<0.

ECMO Survivors' Reflections on Their ICU Experience and Recovery.

Objective: As pediatric mortality improves, approaches to pediatric critical care now focus on understanding long-term implications of survivorship on patients and families. We aimed to characterize how patients recall time spent sedated and recovering to identify areas for improvement in patient outcomes.

Methods: We undertook qualitative analysis using semistructured interviews of pediatric patients requiring extra-corporeal support in our intensive care units from 2018 to 2023.

Cell type specific suppression of hyper-recombination by human RAD18 is linked to PCNA K164 ubiquitination.

Homologous recombination (HR) and translesion synthesis (TLS) promote gap-filling DNA synthesis to complete genome replication. One factor involved in both pathways is RAD18, an E3 ubiquitin ligase. Although RAD18's role in promoting TLS through the ubiquitination of PCNA at lysine 164 (K164) is well established, its requirement for HR-based mechanisms is currently less clear.

Perioxygenation During Advanced Airway Management.

Advanced airway management is a skill that is used every day in patient care settings throughout the world. Albeit common, it is not benign. Advanced airway management may either be elective or urgent; in either case, it may result in significant patient morbiidity and mortality.