Publications by authors named "E L De Mik"
Background: Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication of cardiac surgery and is associated with increased morbidity and mortality. Recent guidelines emphasize the need for new monitoring methods to facilitate targeted CSA-AKI prevention and treatment strategies. In vivo real-time measurement of mitochondrial oxygen tension (mitoPO), could potentially fulfil this role during cardiac surgery, as suggested in our previous pilot study.
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- The study investigates the effect of red blood cell (RBC) transfusions on mitochondrial oxygen tension (mitoPO) and mitochondrial oxygen consumption (mitoVO) in critically ill patients suffering from anemia, with a focus on patients having hemoglobin levels below 10 g/dL.
- Involved 63 patients, measuring mitoPO and mitoVO at various time points surrounding the transfusion; results showed no significant changes in mitoPO and mitoVO before and after the transfusion, even with varying hemoglobin concentrations.
- The findings suggest that RBC transfusions did not improve mitochondrial oxygen measures, indicating that these values are not strongly correlated with hemoglobin levels or typical indicators of tissue oxygenation and
Article Synopsis
- The field of medical grade footwear is transitioning from individual expertise to a more evidence-based approach, but currently lacks sufficient scientific data, making a research agenda essential for growth.
- A multidisciplinary team followed a structured seven-step methodology to develop this research agenda, gathering insights from various stakeholders including pedorthists, rehabilitation physicians, and users.
- The process involved surveying 109 participants, generating 228 potential research questions, narrowing them down to 65 prioritized questions, and ultimately creating a final research agenda with 26 questions ready for implementation through collaborative research projects.
Objectives: Hypertrophic obstructive cardiomyopathy (HOCM) may be treated by septal myectomy. Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common complication, but little is known about its incidence after septal myectomy. The objectives of this work were to evaluate the prevalence of CSA-AKI after septal myectomy and identify potential perioperative and phenotype-related factors contributing to CSA-AKI.
View Article and Find Full Text PDFObjectives: Describing mitochondrial oxygenation (mitoPO2) and its within- and between-subject variability over time after 5-aminolevulinic acid (ALA) plaster application in healthy volunteers.
Design: Prospective cohort study.
Setting: Measurements were performed in Leiden University Medical Center, the Netherlands.