Publications by authors named "E L Chuang"

Autologous or allogeneic platelet-derived extracellular vesicles (pEVs) show potential in enhancing tissue recovery and healing chronic wounds. pEVs promote neovascularization and cell migration while reducing inflammation, oxidative stress, and scarring. However, their efficacy in clinical settings is challenged by their susceptibility to washout by wound exudate.

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The hexameric AAA+ disaggregase, Hsp104, collaborates with Hsp70 and Hsp40 via its autoregulatory middle domain (MD) to solubilize aggregated proteins. However, how ATP- or ADP-specific MD configurations regulate Hsp104 hexamers remains poorly understood. Here, we define an ATP-specific network of interprotomer contacts between nucleotide-binding domain 1 (NBD1) and MD helix L1, which tunes Hsp70 collaboration.

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Article Synopsis
  • The study evaluated the sustainability of 26 Whole Person Care pilots in California that integrated medical and social services for Medicaid enrollees.
  • Key factors affecting sustainability included the program's adaptability, funding structures, and collaborative leadership with managed care plans.
  • Many pilots struggled with sustainability due to challenges posed by system and policy changes when transitioning services into Medicaid benefits, especially in rural areas.
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Objective: To identify collaboration strategies used to integrate health, behavioral health, and social services for Medicaid members in California's Medi-Cal Whole Person Care Pilot program (WPC).

Data Sources And Study Setting: WPC was a social care intervention implemented to identify and address eligible members' health, behavioral health, and social needs. Data included semi-structured key informant interviews conducted in 2018-2019 (n = 221) and 2021 (n = 167); pilot-level surveys; whole-network surveys of 507 organizations in all 25 pilots participating in WPC; and documents submitted by pilots to the state.

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Article Synopsis
  • The recent surge in syphilis cases in the U.S. poses significant public health challenges, particularly due to intermittent shortages of benzathine penicillin, the primary treatment for the infection.
  • Experts from the National Institute of Allergy and Infectious Diseases (NIAID) gathered in February 2024 to explore alternative therapies for treating syphilis, focusing on existing antibiotics with good safety profiles.
  • Workshop discussions highlighted difficulties in designing clinical trials for alternative treatments due to penicillin's high effectiveness and varied patient demographics and health conditions.
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