Borden Institute Records 35 Years of Excellence in Military Medical Publishing.

The Borden Institute, an agency of the US Army Training and Doctrine Command (TRADOC), Medical Center of Excellence (MEDCOE), is marking 35 years of excellence in publishing academic military medical textbooks in the year 2022.

Effects of cortisol on cardiac myocytes and on expression of cardiac genes in fetal sheep.

In 17 fetal sheep aged 129 days, the effects of large-dose infusions of cortisol (72.1 mg/day for 2-3 days) on proliferation, binucleation, and hypertrophy of cardiac myocytes, cardiac expression of angiotensinogen, angiotensin receptor subtypes 1 and 2, Glut-1, glucocorticoid and mineralocorticoid receptors, proteins of the MAPK pathways and calcineurin were studied. Cortisol levels were 8.

Apoptosis-related mitochondrial dysfunction in the early postoperative neonatal lamb heart.

Background: In the early postoperative period, the neonatal myocardium undergoes sparse apoptotic cell loss ( approximately 1% of myocytes). Because apoptosis is preceded by events associated with mitochondrial dysfunction, the fraction of myocytes with preapoptotic mitochondrial changes has important clinical implications (eg, postoperative myocardial dysfunction). My colleagues and I therefore hypothesized that postoperative apoptotic myocytes represent a tip of the iceberg, with more myocytes upstream with apoptosis-related mitochondrial dysfunction (ARMD).