Spatial architecture of biliary tree in mammals: Fractal and Euclidean geometric features.

The study of the fractal architecture of various organs and structures expanded the possibilities for determining the ranges of their functioning and structural arrangement, which, as a result, was reflected in the development of new approaches to diagnostics and therapeutic impacts. The architecture of the excretory duct systems, similar to the hemo- and lymph- circulatory beds and the bronchial tree, is considered fractal. At the same time, information about hitherto unknown structures of the biliary tree continues to appear in the literature.

New corrosion cast media and its ability for SEM and light microscope investigation.

SEM of corrosion casts (CC) provides the opportunities to study the vessels and ducts in the phyllogenetic and ontogenetic (age-related) settings, as well as the pathogenesis, compensation, and sanogenesis in different diseases and experimental models. Along with the refinement of SEM CC, the requirements toward casting media (CM) as nontoxicity, low viscosity, quick polymerization, resistance to corrosion solutions, availability, and so on, gradually has developed. We aimed to adapt the sets widely used in dental practice toward the modern requirements to the CC.

DUCTULAR REACTION AT THE EARLY AND LATE STAGES OF BILIARY OBSTRUCTION: IS THE MECHANISM THE SAME?

Ductular reaction (DR) is one of the classical features of biliary obstruction in humans as well as in experimental models. It is the histological phenomenon expressed by the increased number of ductular profiles (DPs), which is especially intensively studied in rodents' model of common bile duct ligation (CBDL). However, some issues related with DR in long-term CBDL are not clear enough.

Ductular reaction at the early terms of common bile duct ligation in the rats.

Ductular reaction (DR) in bile duct ligated rats generally appears from 2nd day after biliary obstruction (BO). However, we show that increased amount of ductular profiles is evident already in 6 hours after BDL. The study aims to explain the origin of such an early DR in response to BO.

[Optimization of the venous return during experimental hepatectomy in rabbits].

A traditional bypass pattern applied in hepatectomy (venous return in superior vena cava system) is frequently attended by blood congestion in cranial veins. The study objective is the maintenance of hemodynamic indices in normal physiological ranges via application of the new bypass scheme in the experimental model of the anhepatic period. 12 rabbits of Chinchilla breed were involved in the experiments, with weight ranging between 3,0-3,5 kg, which were divided into three groups (with 3 animals in each): I control group - hepatectomy under the condition of non-compulsory liver bypass with the return of the venous flow in brachiocephalic vein.