Publications by authors named "E L Ames"
Unlocking the Mechanisms of Hidradenitis Suppurativa: Inflammation and miRNA Insights.
Clin Cosmet Investig Dermatol
December 2024
Inflammatory skin diseases impose a significant burden on patients and healthcare systems worldwide. Among these, hidradenitis suppurativa (HS) is particularly notable for its chronic and recurrent nature. Recurrent nodules, abscesses, and scarring in apocrine gland-rich areas characterize the disease, including the groin, axillae, and perianal regions.
View Article and Find Full Text PDFArticle Synopsis
- A study called ACTION-Galactosemia Kids evaluated the effects of govorestat, a drug for Classic Galactosemia, on children aged 2-17 by comparing it to a placebo over 18 months.
- Govorestat showed a significant and lasting reduction in plasma galactitol levels, leading to stabilization or improvement in various clinical measures like behavior and daily living skills, while the placebo group showed decline.
- Despite its benefits, govorestat did not show improvements in speech or gross motor skills, and both the drug and placebo groups experienced similar rates of adverse effects, indicating it is safe and well tolerated.
Clinical tools that can aid in the diagnostic differentiation of juvenile dermatomyositis from muscular dystrophy.
View Article and Find Full Text PDFThe increasing availability of clinically approved genetic tests for kidney disease has spurred the growth in the use of these tests in kidney transplant practice. Neither the testing options nor the patient population where this should be deployed has been defined, and its value in kidney transplant evaluation has not been demonstrated. Transplant providers may not always be aware of the limitations of genetic testing and may need guidance on comprehending test results and providing counsel, as many centers do not have easy access to a renal genetic counselor or a clinical geneticist.
View Article and Find Full Text PDFArticle Synopsis
- Current ultrasound-guided IV access training models are expensive and lack realistic complexity, prompting the development of a cost-effective gelatin model that mimics real vein and artery interactions.
- A study at the University of Nevada tested this advanced model against traditional options, finding that participants with limited ultrasound experience reported significantly higher confidence levels after using the new model.
- Statistical analysis demonstrated that the advanced model resulted in greater perceived skill improvement, with participants showing an increase of over 4 points in comfort levels on a five-point scale.