Interaction of BODIPY Dyes with the Blood Plasma Proteins.

Photophysical properties of several BODIPY-based fluorescent dyes were investigated in systems containing blood plasma biomolecules and in model system containing bovine serum albumin in terms of electronic absorption and fluorescence spectroscopy. The interaction between the investigated dyes and protein plasma components changes spectral characteristics of the dyes and leads to bathochromic and hypochromic absorption spectra shifts accompanied by changing of fluorescence intensity. The mechanism of fluorescence changing was defined in the terms of Stern-Volmer theory.

[Protective role of cobalt complexes of porphyrin and phthalocyanine in acute nitrite intoxication and endotoxic shock in an experiment].

There is currently an active search for effective agents to regulate the content of nitric oxide (NO) in the body. One of the ways of reducing its blood concentration may be the binding of NO by different complexions that comprise the metal complexes of porphyrins and phthalocyanines. The study was undertaken to evaluate the protective effect of synthetic metal complexes of porphyrin and phthalocyanine in acute nitrite intoxication and endotoxic shock.