Publications by authors named "E L Aho"
Article Synopsis
- Age-related macular degeneration (AMD) is a common cause of vision loss among older adults, and current treatment options are limited.
- Researchers identified genetic factors contributing to AMD risk by analyzing data from 12,495 AMD cases and 461,686 controls, discovering four key protective haplotypes.
- The study suggests that lowering levels of the protein FHR-5 could enhance certain immune pathways and potentially serve as a strategy to prevent or treat AMD.
Article Synopsis
- - The paper highlights the increasing difficulty in maintaining access to both old and new antibiotics, leading to negative impacts on healthcare and a rise in antibiotic resistance due to the use of less effective alternatives.
- - It identifies four types of antibiotic unavailability—short-term shortages, long-term shortages, deregistrations, and lack of registration—explaining their causes, consequences, and potential solutions, supported by examples from Norway, Romania, and Ethiopia.
- - Understanding the specific type of antibiotic unavailability is crucial for finding effective solutions, as strategies like stockpiling may only be effective for certain circumstances and won't address every issue related to access.
Background: The advancement of diagnostic and therapeutic interventions in early Alzheimer's disease (AD) has demanded the economic evaluation of such interventions. Resource utilization and cost estimates in early AD and, more specifically, the amyloid-positive population are still lacking. We aimed to provide cost estimates in AD in relation to disease severity and compare these with the control population.
View Article and Find Full Text PDFBackground: Although dementia incidence has decreased in high-income countries, it is important to monitor the prevalence of dementia and identify potential underdiagnosis in population subgroups. This study provides the most up-to-date prevalence of dementia diagnosis in Sweden, by geographical regions and sociodemographic groups.
Methods: We identified all individuals aged ≥62 years, registered and alive in Sweden at the end of 2022 (n = 2.
Antiandrogen treatment resistance is a major clinical concern in castration-resistant prostate cancer (CRPC) treatment. Using xenografts of VCaP cells we showed that growth of antiandrogen resistant CRPC tumors were characterized by a higher intratumor dihydrotestosterone (DHT) concentration than that of treatment responsive tumors. Furthermore, the slow tumor growth after adrenalectomy was associated with a low intratumor DHT concentration.
View Article and Find Full Text PDF