Bioenergy sorghum nodal root bud development: morphometric, transcriptomic and gene regulatory network analysis.

Bioenergy sorghum's large and deep nodal root system and associated microbiome enables uptake of water and nutrients from and deposition of soil organic carbon into soil profiles, key contributors to the crop's resilience and sustainability. The goal of this study was to increase our understanding of bioenergy sorghum nodal root bud development. Sorghum nodal root bud initiation was first observed on the stem node of the 7 phytomer below the shoot apex.

Recon8D: A metabolic regulome network from oct-omics and machine learning.

The complexity and incompleteness of metabolic-regulatory networks make it challenging to predict metabolomes from other omics. Using machine learning, we predicted metabolomic variation across ~1000 different cancer cell lines from matched oct-omics data: genomics, epigenomics (histone post-translational modifications (PTMs) and DNA-methylation), transcriptomics, RNA splicing, miRNA-omics, proteomics, and phosphoproteomics. Overall, the metabolome is tightly associated with the transcriptome, while miRNAs, phosphoproteins and histone PTMs have the highest metabolic information per feature.

Advanced Care Planning in Chronic Kidney Disease: Qualitative Impact of the MY WAY Intervention.

Context: Despite recommendations for shared decision-making and advanced care planning (ACP) for people with chronic kidney disease (CKD), such conversations are infrequent. The MY WAY educational and patient coaching intervention aimed to promote high-quality ACP.

Objectives: This qualitative substudy sought to gain participant feedback on the MY WAY ACP coaching intervention, and how it impacted their wishes, perceptions of kidney care, and factors that helped them reflect on ACP.

PLAT domain protein 1 (PLAT1/PLAFP) binds to the Arabidopsis thaliana plasma membrane and inserts a lipid.

Robust agricultural yields depend on the plant's ability to fix carbon amid variable environmental conditions. Over seasonal and diurnal cycles, the plant must constantly adjust its metabolism according to available resources or external stressors. The metabolic changes that a plant undergoes in response to stress are well understood, but the long-distance signaling mechanisms that facilitate communication throughout the plant are less studied.