Correlation of Salusin Beta with hs-CRP and ADMA in Hypertensive Children and Adolescents.

Purpose: The emerging evidence has recently shown an evident dependence between recently identified salusin peptides and atherosclerosis, and their important roles as endogenous modulators of atherogenesis. It was reported that the development of atherosclerosis could also be affected by endogenous salusin- β overproduction in vascular lesions.

Materials/methods: This prospective cohort study was conducted in two groups of children: HT - 58 patients with essential hypertension (HT); R - 30 participants with white-coat HT (R).

Does obesity or hyperuricemia influence lithogenic risk profile in children with urolithiasis?

Background: There are indications that obesity and hyperuricemia may influence the formation and composition of urinary stones. The aim of our study was to determine the effect of obesity and hyperuricemia on the urinary lithogenic risk profile in a large cohort of pediatric patients.

Methods: The study population comprised 478 children with urolithiasis and 517 healthy children (reference group).

Is the serum level of salusin-β associated with hypertension and atherosclerosis in the pediatric population?

Background: Salusins are recently identified endogenous bioactive peptides that have hypotensive and bradycardiac effects. Salusin-β is involved in the pathogenesis of human atherosclerosis.

Methods: This was a prospective cohort study of a young patient population with hypertension (HTN).

Urine L-carnitine excretion in hypertensive adolescents.

Aim: This study was performed to test the hypothesis that urinary levels of L-carnitine and its derivatives are enhanced in children and adolescents with hypertension and also check if analyzed parameters may serve as early markers of subclinical renal damage.

Methods: The study included 112 children and adolescents (67 males and 45 females) aged median 10-18 years. Participants were divided into two groups: HT-64 subjects with confirmed primary hypertension and R-reference group-48 subjects with white-coat hypertension.

Urinary angiotensinogen as a marker of intrarenal angiotensin II activity in adolescents with primary hypertension.

Background: Experimental and epidemiological studies have demonstrated that urinary angiotensinogen (AGT) is a novel biomarker for the intrarenal activity of the renin-angiotensin system in hypertension (HT). Several large-scale epidemiological studies have shown that an elevated serum uric acid (SUA) level is associated with HT. The aim of our study was to assess urinary AGT excretion and its correlation with SUA level, the lipid profile, and the body mass index (BMI) Z-score in hypertensive adolescents.