[The role of free fatty acids in the pathogenesis of arteriosclerosis].

Several diseases and functional disturbances (e.g. diabetes mellitus, obesity, phaeochromocytoma, chronic renal functional disturbances, psychosocial stress) marked by a disturbed metabolism of free fatty acids (FFA) and a hyperlipacidaemia correlate with a premature occurrence of arteriosclerotic alterations of the vessels.

[Metabolism of free fatty acids in muscles].

The skeletal muscle and the myocardium (musculature) are involved in the turnover rate of free fatty acids (FFA) with a third. Disturbances of the FFA metabolism of the musculature result in a restriction of the function which appears as a diminished contractility and, as far as the myocardium is concerned, additionally as arrhythmias. Moreover the restriction of the FFA utilization by the muscles plays a role in the origin of hyperlipacidaemias participating in the pathogenesis of various acute and chronic extramuscular functional disturbances (e.

[The metabolism of free fatty acids in the liver].

The liver participates in the turnover rate of free fatty acids (FFA) with a third. A severe disruption of liver function that occurs in cirrhosis leads therefore to a pathogenetic relevant hyperlipacidaemia respectively increases that. With regard to its clinical relevance a survey is given of the FFA metabolism of the liver.

[Metabolism of free fatty acids in fatty tissue].

Hyperlipacidaemias play a role as etiological partial factor in the pathogenesis of various acute and chronic functional disturbances and are essentially the sequel of a disturbed metabolism of the free fatty acids of the fatty tissue. With regard to its clinical relevance a survey is given of the free fatty acid metabolism of the fatty tissue and its free fatty acid net balance as resultants from lipolysis and triglyceride synthesis is described. The author deals with the regulation of the lipolysis by cyclic mononucleotides, adenosine triphosphate, adenosine, fatty acids, ions, beta-hydroxybutyrate, lactate as well as hormones and finally with the control of the triglyceride synthesis.

[Lipid parameters in newly detected type II diabetic patients and relations to coronary heart disease].

In a prospective study 192 new manifested type 2 (noninsulin dependent) diabetics were checked in view of prevalence of coronary heart disease (CHD) and hypertension in relation to concentration of lipids in serum. CHD was found in 49%, hypertension in 53% dominating females. Increased triglycerides (1.