Publications by authors named "E Krustev"
Article Synopsis
- Cranial neuropathies (CN) are a rare manifestation of neuropsychiatric lupus, and the study investigates the association of anti-KIF20B antibodies as a possible biomarker for this condition within a large cohort of SLE patients.
- The research involved 795 patients from a larger cohort, revealing that 29.8% were positive for anti-KIF20B, with a significantly higher positivity rate (70%) in those with CN compared to those without (29.3%).
- Findings suggest that anti-KIF20B positivity is linked to CN in SLE patients, indicating its potential as a biomarker, though further research is required to confirm these results.
B cell depletion and inhibition in systemic lupus erythematosus.
Expert Rev Clin Immunol
January 2023
Introduction: Systemic lupus erythematosus (SLE) is characterized by autoantibody expression and aberrant autoreactive B cells contribute to disease progression; therefore, B cell inhibition has been an attractive target for novel therapies. However, after more than two decades of research and over 40 randomized clinical trials, only one such therapy, belimumab, has been approved for use in SLE.
Areas Covered: In this review, we discuss the evidence for B cell-targeted therapies in SLE and lupus nephritis.
Article Synopsis
- Researchers have found that α-1-Antitrypsin (AAT) shows potential in protecting cartilage and reducing inflammation and pain in models of rheumatoid arthritis.
- AAT treatment led to improved gene expression related to cartilage health and reduced detrimental gene expression in arthritic joints.
- The study suggests that AAT may serve as a promising new therapy to alleviate pain and promote cartilage repair in arthritis patients.
Background Knee joint injections and aspirations are essential procedures for medical students, residents, and primary care physicians to master. Simulation-based training has been shown to improve learner confidence and performance scores in knee joint injections. Current knee joint simulators are expensive, ranging from hundreds to thousands of dollars.
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- Mediators like neutrophil elastase are linked to joint pain in osteoarthritis (OA) and inflammation caused by injury or irritation.
- In a study using male mice, researchers injected monoiodoacetate (MIA) into knee joints to simulate OA and observed the effects of neutrophil elastase and proteinase-activated receptor-2 (PAR2) on joint inflammation and pain over 14 days.
- Results showed that MIA increased neutrophil elastase activity and joint pain early on, with treatments targeting neutrophil elastase and PAR2 leading to improvements in inflammation and nerve damage.