Publications by authors named "E Kramme"
An important prerequisite for ascertaining rational antibiotic prescribing is the availability and evaluation of antibiotic use data. In this study we report evolving trends of antibiotic use in German hospitals during the last decade.Using drug dispensing data from acute care hospital pharmacies, we calculated yearly antibiotic use density values for the period from 2012/13 through to 2021/22.
View Article and Find Full Text PDFPurpose: To analyze the longitudinal epidemiology and antimicrobial resistance (AMR) patterns of Gram-negative bloodstream infections (BSI) in Germany.
Methods: Post-hoc analysis of prospectively documented BSI due to Escherichia coli, Klebsiella spp., Enterobacter spp.
Background: The patterns and intensity of inpatient antibiotic prescribing vary according to medical specialty.
Objectives: Analysis of recent data on antibiotic use density in hospital departments of urology in Germany.
Methods: Annual surveillance data of 107 departments for the period 2022/2023 were evaluated.
Background: Previous studies found that the coronavirus disease 2019 (COVID-19) pandemic had a variable impact on the consumption of antimicrobial drugs in human medicine, with trends in several European countries differing between community and inpatient prescribing.
Aim: This study analysed changes in the volumes and use density of antibacterial and antifungal drugs dispensed in acute care hospitals in Germany between 2019 and 2022.
Methods: Surveillance data for the four years available from 279 hospitals were expressed as the total volumes of daily doses or as use density (daily doses per 100 patient/occupied bed days) per year and analysed descriptively, using recommended hospital-adapted daily dose definitions (RDDs) and (as sensitivity analysis) WHO/ATC-defined daily dose definitions (DDD).
Article Synopsis
- The executive summary outlines evidence-based recommendations for diagnosing and treating nosocomial pneumonia, focusing on practical guidelines for healthcare providers in Germany.
- It was developed through a systematic review process by an interdisciplinary panel, with the help of an independent methodologist, and presents 26 total recommendations, including ones based on strong evidence and expert consensus.
- Key recommendations include distinguishing patients at risk for multidrug-resistant pathogens, limitations of routine bacterial PCR testing, and guidelines for antibiotic therapy, emphasizing focused treatments and the importance of rapidly de-escalating unnecessary antibiotics when patients stabilize.