Publications by authors named "E Koyama"
Four new bisindole alkaloids, cathagines A (1)-D (4) consisting of an aspidosperma and the fused tetracyclic 3-spirooxindole derived from an iboga type skeleton were isolated from the whole plant of Catharanthus roseus. The structures including absolute stereochemistry were elucidated on the basis of 2D NMR data and CD spectra. Cathagine B (2) showed moderate anti-malarial activity against Plasmodium falciparum 3D7.
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- Understanding matrix molecular activities is key for developing regenerative strategies for TMJ disorders, with a focus on how collagen V impacts the growth and remodeling of condylar cartilage and the articular disc.
- The study found that loss of collagen V significantly affects the proliferation and density of progenitor cells in condylar cartilage but has less impact on the disc cells, which behave more like fibroblasts.
- Under conditions of altered occlusal loading, cartilage from mice lacking collagen V showed more degeneration and hypertrophy compared to wild-type, highlighting collagen V's critical role in condylar cartilage, suggesting its potential for enhancing TMJ regeneration in patients.
Background: Although femoropopliteal-specific stents have durable patency, stent thrombosis (ST) may occur, which can lead to acute limb ischaemia (ALI).
Aims: We aimed to investigate the clinical features and outcomes of ALI caused by femoropopliteal ST in patients with lower extremity artery disease.
Methods: This multicentre retrospective study included 499 patients with ALI - of whom 108 patients had ALI caused by femoropopliteal ST (ST-ALI) and 391 patients had ALI caused by other aetiologies (de novo ALI) - who underwent treatment between September 2011 and March 2023.
Excessive and persistent aggressiveness is the most common behavioral problem that leads to psychiatric referrals among children. While half of the variance in childhood aggression is attributed to genetic factors, the biological mechanism and the interplay between genes and environment that results in aggression remains elusive. The purpose of this systematic review is to provide an overview of studies examining the genetics of childhood aggression irrespective of psychiatric diagnosis.
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- Photoresponsive liquid-crystalline elastomers (LCEs) show potential as soft actuators that can be controlled by light, with their mechanical properties changing under light exposure.
- The study explores how varying stress/strain levels and polymer network characteristics, influenced by solvent amount, affect the performance of LCEs, revealing complex relationships between mechanical behavior and synthesis conditions.
- Results indicate that while increasing solvent reduces certain mechanical properties, it enhances others, and the overall performance peaks at specific operating conditions, which is essential for the design of LCE-based devices.