Publications by authors named "E Kovzel"
Background: To date, several questionnaires have been developed as easy-to-use screening tools for assessing and monitoring asthma control as the Asthma Control Test (ACT). However, the assessment of the reliability of the ACT questionnaire translated into the Kazakh language has not been carried out yet. The study aimed to evaluate the reliability and validity of the Kazakh-language ACT questionnaire as an asthma control tool.
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- DiGeorge syndrome (DGS) is a genetic disorder caused by microdeletions in the 22q11.2 region, leading to a range of developmental abnormalities, with a prevalence of about 1 in 4000 births.
- A new multiplex droplet digital PCR (ddPCR) assay was developed to accurately detect and map these microdeletions by amplifying specific targets and including an internal control.
- The assay proved effective in clinical samples, identifying microdeletions and correlating changes in immune cell counts, indicating its potential for reliable DGS diagnosis using blood samples.
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- The J Project (JP) is a collaborative program aimed at improving physician education and clinical research on inborn errors of immunity (IEI), established in 2004 and currently spanning 32 countries, primarily in Eastern and Central Europe.
- By the end of 2021, JP organized 344 meetings to enhance awareness and improve diagnosis and treatment for patients with IEI, with a significant increase in annual meetings over the years.
- Data from patient reports across 30 countries indicated a prevalence of 4.9 patients per population, mostly featuring patients with predominantly antibody deficiency, along with a strong commitment to treatments like immunoglobulin substitution and hematopoietic stem cell therapy.
SARS-CoV-2 pandemic had a general and deep impact on the clinical management of chronic diseases, including respiratory and allergic disorders. At the beginning of the pandemic, one of the main concerns was the potential impact of immunosuppressive/immunomodulatory drugs on COVID-19 clinical course. In this review, we aim to summarize and analyze the available clinical evidence from patients treated with anti-type 2 inflammation biologics (including anti-IgE, anti-IL-5 and anti-IL-4 agents), who developed COVID-19.
View Article and Find Full Text PDFDysregulation of the immune system occurs when the immune system cannot regulate normal control of inflammation, which leads to the most common severe inflammatory infections. Some of the manifestations of diseases of immune dysregulation are called diseases of increased function of STAT1 (GOF) and enhanced function of STAT3 (GOF). STAT stands for a kind of signal converter and transcription activator.
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