Association of cephalosporin resistance in intraoperative biliary cultures with surgical site infections in patients undergoing pancreaticoduodenectomy. A retrospective cohort study.

Background: The aim of this study was to assess the incidence of bacterobilia at the time of a pancreaticoduodenectomy (PD) and the association of resistant bacteria in bile to surgical site infections (SSI).

Methods: This was a retrospective cohort study including patients undergoing PD in a single center between May 2016 and October 2020. Data of preoperative biliary drainage (PBD), intraoperative biliary cultures (IBC) and postoperative complications were analysed to assess the risk factors for resistant bacteria in IBC and SSIs.

Clinical and microbiological factors associated with mortality in candidemia in adult patients 2007-2016.

Candidemia is a life-threatening infection with high mortality. Our aim was to evaluate the species distribution, antifungal susceptibilities and risk factors associated with 30-day mortality in candidemia in Southern Finland. We present a retrospective analysis of candidemia cases from the hospital district of Helsinki and Uusimaa during 2007-2016.

Capnocytophaga canimorsus bacteremia: clinical features and outcomes from a Helsinki ICU cohort.

Background: Capnocytophaga canimorsus is a gram-negative rod capable of causing severe sepsis or septic shock. We studied the characteristics of patients with C. canimorsus bacteremia treated in intensive care unit (ICU).

Targeting matrix metalloproteinases with intravenous doxycycline in severe sepsis--A randomised placebo-controlled pilot trial.

An overwhelming inflammatory process is the hallmark of severe sepsis and septic shock. Matrix metalloproteinases (MMPs)-8 and -9 are released from neutrophils and activated in sepsis to participate in inflammation in several ways. High levels of MMP-8 may associate with increased ICU mortality.

[Botulism].

Botulism is a rare but potentially life-threatening disease caused by Clostridium botulinum neurotoxin. In Finland only a few cases have been diagnosed during the past ten years but mild cases may be underdiagnosed. The diagnosis of botulism is clinical.