Caspase 9-induced apoptosis enables efficient fetal cell ablation and disease modeling.

Fetal cell ablation models are crucial for studying congenital diseases, organ regeneration, and xenotransplantation. However, conventional knockout models offer limited control over disease severity, while conditional ablation models often require fetus-harming inducers. In the present study, we demonstrate that the inducible caspase 9 system enables precise targeting of fetal nephron progenitor cells in mice through the intrinsic apoptotic pathway.

Effect of participating in Kayoi-no-ba during the COVID-19 pandemic on frailty 1 year later in older adults.

Aim: This study examined the short-term effects of participation in Kayoi-no-ba - community gathering places for residents to contribute to care prevention with the support of volunteers in Japan - on frailty status during the coronavirus disease 2019 (COVID-19) pandemic, based on a 1-year longitudinal study of older adults.

Methods: Participants (n = 3899) were aged ≥65 years. At baseline, they were classified into four groups, based on their frequency of participation in Kayoi-no-ba before and after the COVID-19 pandemic: the nonparticipation group, the continued participation group, the interrupted participation group and the new participation group.

ILAE neuroimaging task force highlight: The utility of multimodal neuroimaging in diagnostic and presurgical workup of drug-resistant focal epilepsy.

The ILAE Neuroimaging Task Force publishes educational case reports that highlight basic aspects of neuroimaging in epilepsy, consistent with ILAE's educational mission. In patients with drug-resistant focal epilepsy who are candidates for surgical intervention, the identification of structural abnormalities is a strong predictor of favorable postoperative seizure outcomes. When conventional imaging is insufficient, the integration of multimodal neuroimaging data with structural, metabolic, and functional imaging modalities is often helpful.

Reversed loneliness development after age 65 for men and women: Modeling of the age trajectories of loneliness using national cohorts in Taiwan and Japan.

Aim: This study depicts the age trajectories of loneliness and gender differences among older adults in Taiwan and Japan.

Methods: Two nationally representative data sets for older adults in Taiwan and Japan were obtained from the Taiwan Longitudinal Study on Aging (TLSA, 1996-2011) and the National Survey of the Japanese Elderly (NSJE, 1996-2012), respectively. The analytic sample included 3037 and 1974 older adults aged 65 and over at baseline in Taiwan and Japan, respectively.

Long Term Follow Up of Children Who Received Rapid Genomic Sequencing.

Purpose: To explore long-term trajectories of children who received rapid genome sequencing (RGS) in intensive care settings.

Methods: We examined the electronic health records (EHR) of 67 critically ill pediatric patients who received RGS six to eight years ago with a collective initial diagnostic yield of 46%.

Results: The median length of follow up was 6.