Medical therapy of Graves' disease: effect on remission rates of methimazole alone and in combination with triiodothyronine.

In a prospective, randomized study of 135 newly diagnosed patients with hyperthyroidism due to Graves' disease we compared the effect on remission rates of additional triiodothyronine (T3) with conventional antithyroid drug therapy. To this end 114 patients were followed for at least 12 months (15.7+/-4.

[The "cold" nodule of the thyroid gland: 20 years experience with 2,071 patients and diagnostic limits of fine needle biopsy].

The files of 2071 patients with (Tc99m)-scintigraphically "cold" thyroid nodules (CTN) attending a teaching hospital were analysed retrospectively. Between 1975 and 1995 altogether 49 endocrinologists with varying degrees of experience carried out the clinical evaluation as well as fine needle aspiration biopsy (FNAB), and 33 pathologists undertook the cytological interpretation. By clinical criteria the CTN of 1272 patients were deemed benign, whilst malignancy was suspected in 301 patients (81% and 19% of evaluable cases, respectively).