Gastroprotective effect of propacetamol against cold/restraint stress ulcers in rats.

Background: Comparative evaluation of propacetamol and morphine on the cold restraint stress ulcers in rats.

Methods: The present study compared the effects of propacetamol hydrochloride (250 and 500 mg.kg-1 i.

Effect of roxatidine bismuth citrate (MX1) against acetylsalicylic acid- and indomethacin-induced gastric mucosal damage in rats.

We have studied the effect of the newly synthesized agent, roxatidine bismuth citrate (N-[3-(3-(1-piperidinyl-methyl)phenoxy)propyl]-hydroxyacetamide-2- hydroxypropane-1,2,3-tricarboxylate-bismuth(3+) complex), code name MX1, against acetylsalicylic acid (ASA)- and indomethacin-induced gastric mucosal damage in rats. Effects of MX1 (12.5, 50, 125, 184, 250 mg/kg) were compared to the effects of equimolar doses of roxatidine and bismuth subcitrate.

Gastroprotective effect of MX1 (a novel salt of the active metabolite of roxatidine with a complex of bismuth and citric acid) against stress ulcers in rats.

We have studied the effect of the newly synthesized agent MX1, a salt of the active metabolite of the H2-blocker roxatidine with a complex of bismuth and citric acid (N-[3-(3-(1-piperidinylmethyl)phenoxy)propyl]-hydroxyacetamide+ ++ -2-hydroxypropane-1,2,3-tricarboxilate-bismuth(3+) complex), against restraint stress ulcers in rats (24 h immobilization). The effects of MX1 (12.5, 50, 125, 184 and 250 mg kg-1) were compared with the effects of equimolar doses of roxatidine (6.

[The effect of an extract of sea buckthorn (Hippophae rhamnoides L.) on the healing of experimental skin wounds in rats].

The effect exerted by Hippophaë rhamnoides L. extract on the healing of experimental wounds in rats is studied histomorphologically in dynamics. The animals are divided up in three groups, as follows: group one--controls, group two--controls treated with indifferent carrier (carbopol gel), and group three--experimental, treated with carbopol gel containing extract of Hippophaë rhamnoides L.

[A pharmacological study of the hepatoprotective activity of fructose-1,6-diphosphate].

A fructose-1,6-diphosphate preparation was tested for hepatoprotective activity through biochemical and morphologic studies in experiments on Wistar rats sustaining D-galactosamine- and paracetamole-induced hepatotoxicity. Findings indicated the modeled hepatic lesions to be readily reproducible, to simulate some characteristics of human liver pathology, and to be suitable for testing substances expected to have hepatoprotective action; intraperitoneal administration of fructose-1,6-diphosphate at a dose of 1000 mg/kg body weight proved moderately protective against liver damage by D-galactosamine; the benefit observed concerned mostly dystrophic and inflammatory changes in the liver; in a number of cases, correlation was noted between biochemical serum parameters and pathomorphologic liver alterations.