Publications by authors named "E Klimi"
Article Synopsis
- The study identifies seven microRNAs (miRNAs) that inhibit the proliferation of vascular smooth muscle cells (vSMCs), important in preventing vascular remodeling issues.
- Through high-throughput screening of 2,042 human miRNA mimics, the researchers pinpointed miR-323a-3p, miR-449b-5p, miR-491-3p, miR-892b, miR-1827, miR-4774-3p, and miR-5681b as effective in reducing vSMC proliferation.
- The findings suggest these miRNAs could be developed into therapeutic agents, particularly for conditions like vein graft failure, showing minimal toxicity and altering key cell-cycle gene networks involved in
Vascular smooth muscle cell (vSMC) dysfunction is a critical contributor to cardiovascular diseases, including atherosclerosis, restenosis and vein graft failure. Recent advances have unveiled a fascinating range of non-coding RNAs (ncRNAs) that play a pivotal role in regulating vSMC function. This review aims to provide an in-depth analysis of the mechanisms underlying vSMC dysfunction and the therapeutic potential of various ncRNAs in mitigating this dysfunction, either preventing or reversing it.
View Article and Find Full Text PDFExtracellular vesicles (EVs) released from healthy endothelial cells (ECs) have shown potential for promoting angiogenesis, but their therapeutic efficacy remains poorly understood. We have previously shown that transplantation of a human embryonic stem cell-derived endothelial cell product (hESC-ECP), promotes new vessel formation in acute ischemic disease in mice, likely via paracrine mechanism(s). Here, we demonstrated that EVs from hESC-ECPs (hESC-eEVs) significantly increased EC tube formation and wound closure in vitro at ultralow doses, whereas higher doses were ineffective.
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