Publications by authors named "E Klapproth"

Article Synopsis
  • Radiation-induced morphea (RIM) is an uncommon complication of radiotherapy, mainly seen in breast cancer patients, characterized by inflammatory fibrosis where the underlying mechanisms are not well understood.
  • The study focused on analyzing fibroblasts from RIM patients to find potential therapeutic targets, discovering key differences like increased alpha-smooth-muscle-actin (αSMA) and Myc activation in RIM fibroblasts.
  • Treatment with the anti-inflammatory drug mesalazine was shown to effectively improve patient symptoms by reversing the harmful fibroblast changes and significantly reducing levels of the biomarker osteopontin (OPN).
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Oxygen sensing is of paramount importance for maintaining cellular and systemic homeostasis. In response to diminished oxygen levels, the hypoxia-inducible factors (HIFs) orchestrate various biological processes. These pivotal transcription factors have been identified as key regulators of several biological events.

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Objectives: Myocardial infarction (MI) initiates a complex reparative response during which damaged cardiac muscle is replaced by connective tissue. While the initial repair is essential for survival, excessive fibrosis post-MI is a primary contributor to progressive cardiac dysfunction, and ultimately heart failure. Currently, there are no approved drugs for the prevention or the reversal of cardiac fibrosis.

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Background: Ventricular arrhythmia and sudden cardiac death are the most common lethal complications after myocardial infarction. Antiarrhythmic pharmacotherapy remains a clinical challenge and novel concepts are highly desired. Here, we focus on the cardioprotective CNP (C-type natriuretic peptide) as a novel antiarrhythmic principle.

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