Publications by authors named "E Kieff"
In the version of this Letter originally published, the authors reported on the use of 2,5-dimethylpyrrolyl benzoic acid to block Ephrin receptors. In 2011, it was reported that newly synthesized 2,5-dimethylpyrrolyl benzoic acid lacked the previously reported EphA2 antagonizing activity1. However, the purchased compound did in fact have the activity initially reported, suggesting that an uncharacterized alteration occurred during storage.
View Article and Find Full Text PDFEpstein-Barr virus (EBV) is causally associated with nasopharyngeal carcinoma, 10% of gastric carcinoma and various B cell lymphomas . EBV infects both B cells and epithelial cells . Recently, we reported that epidermal growth factor and Neuropilin 1 markedly enhanced EBV entry into nasopharyngeal epithelial cells .
View Article and Find Full Text PDFEpstein-Barr virus (EBV) transforms B cells to continuously proliferating lymphoblastoid cell lines (LCLs), which represent an experimental model for EBV-associated cancers. EBV nuclear antigens (EBNAs) and LMP1 are EBV transcriptional regulators that are essential for LCL establishment, proliferation, and survival. Starting with the 3D genome organization map of LCL, we constructed a comprehensive EBV regulome encompassing 1,992 viral/cellular genes and enhancers.
View Article and Find Full Text PDFNasopharyngeal carcinoma super-enhancer-driven ETV6 correlates with prognosis.
Proc Natl Acad Sci U S A
September 2017
Article Synopsis
- - Nasopharyngeal carcinoma (NPC) is most prevalent in southern China and southeast Asia, and its occurrence is linked to genetic factors, Epstein-Barr virus (EBV) infection, and environmental influences.
- - Researchers utilized advanced sequencing techniques to analyze the epigenome of NPC tissues and cells, identifying specific enhancers that are associated with oncogenic genes, particularly highlighting the role of ETV6.
- - High expression levels of ETV6 were found in NPC biopsies and were associated with worse patient outcomes, while distinct epigenetic landscapes related to EBV were also characterized in NPC tissues.
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy leukoplakia. We performed systematic quantitative analyses of temporal changes in host and EBV proteins during lytic replication to gain insights into virus-host interactions, using conditional Burkitt lymphoma models of type I and II EBV infection. We quantified profiles of >8,000 cellular and 69 EBV proteins, including >500 plasma membrane proteins, providing temporal views of the lytic B cell proteome and EBV virome.
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