Publications by authors named "E Keith Keenan"
Proinflammatory cytokines and neuropeptides in psoriasis, depression, and anxiety.
Acta Physiol (Oxf)
March 2025
Psoriasis vulgaris has established associations with psychiatric conditions such as depression, anxiety, and chronic stress. This review aims to evaluate current theories and evidence regarding the role of proinflammatory cytokines and neuropeptides in connecting systemic inflammation, psychological stress, and inflammatory skin diseases, namely psoriasis. A literature review was conducted to analyze studies that explore the connections between psoriasis, psychiatric conditions, and biological mediators, including inflammatory cytokines [interferon (IFN)-γ, interleukin (IL)-1, IL-2, IL-6, IL-12, tumor necrosis factor (TNF)-α, IL-22, IL-17], neuropeptides [calcitonin gene-related peptide (CGRP), substance P (SP), and vasoactive intestinal peptide (VIP)], as well as the hypothalamic-pituitary-adrenal (HPA) axis.
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- Researchers studied how people using methadone for treatment are also using other drugs, like cannabis and cocaine, between 2010 and 2020.
- They found that more patients were testing positive for drugs like benzodiazepines and cocaine over time, but fewer were using opioids.
- A lot of patients combined methadone with other drugs, which can be dangerous, and nearly 30% of them had mixed drug use by 2020.
Cysteine is a reactive amino acid central to the catalytic activities of many enzymes. It is also a common target of post-translational modifications (PTMs), such as palmitoylation. This longchain acyl PTM can modify cysteine residues and induce changes in protein subcellular localization.
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