Immunosuppressive treatment for peripheral neuropathies in Sjogren's syndrome - a systematic review.

Background: Sjogren's syndrome (SS) is among the most frequent autoimmune diseases and one of its most severe extraglandular manifestations is peripheral neuropathy. There is no consensus about peripheral neuropathy treatment in SS. Our aim is to identify studies proving the efficiency of immunosuppressive treatment on peripheral neuropathies in SS.

Interaction of heparin with lipoproteins - role of the complex in the inactivation of thrombin and plasmin.

Heparin forms a complex with human low density lipoprotein (LDL) in the presence of Ca2+. The complex is dissociable by 0.5 M NaCl.

Kinetic analysis of the heparin-enhanced plasmin--antithrombin III reaction. Apparent catalytic role of heparin.

Inactivation of plasmin by a 3-4-fold molar excess of antithrombin III follows pseudo-first-order kinetics and the apparent rate constants are proportional to the concentration of the inhibitor. Heparin accelerates the inactivation reaction without changing its pseudo-first-order character, and the apparent rate constants are also proportional to the concentration of the polysaccharide. Heparin results in a minimum 20-fold rate enhancement of the reaction between plasmin and antithrombin III when the concentrations of heparin and plasmin are approx.

Guanosine polyphosphate production of Escherichia coli stringent and relaxed strains in the stationary phase of growth.

Stringent and relaxed Escherichia coli strains grown on minimal and on differently enriched media produced guanosine polyphosphates in the stationary phase of growth. On transition from the logarithmic to the stationary phase, stringent strains started to produce guanosine 5' triphosphate 3' diphosphate (pppGpp). and guanosine 5' diphosphate 3' diphosphate (ppGpp), while relaxes strains accumulated only ppGpp.

Initiation of synthesis of N-terminal acetylated histones with methionine.

The studies presented were undertaken to clarify the unsettled question whether the synthesis of histones with a N-acetylserine residue at the amino terminal end is initiated with methionine. Histones were synthesized in vitro in a rabbit reticulocyte lysate, primed with a mRNA preparation from ascites cells. Initiation of polypeptide synthesis was investigated by using N-formyl[35S]met-tRNAfMet from yeast to label the N-termini.