Publications by authors named "E Kaya"

Objective: Acute graft versus host disease (GVHD) occurs in 20-80 % of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Of these patients, 40 % will be resistant to steroids, which is the standard first-line approach. There is no standard second line treatment approach for patients with steroid refractory acute GVHD (SR-aGVHD).

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Objectives: In this study, we aimed to compare the engraftment days, graft versus host disease (GVHD) development, relapse and overall survival (OS) rates in patients using variable intensity conditioning regimens with two different post-transplant cyclophosphamide (PTCy) doses for hematological malignancies.

Material And Methods: We retrospectively analyzed 162 patients who have had PTCy at a dose of 25 mg/kg × 2 and 50 mg/kg × 2 between 2018 and 2024. Patients were divided in 2 groups; PTCy dose with 25 mg/kg × 2 (Group 1, n = 45) and PTCy dose with 50 mg/kg × 2 (Group 2, n = 117).

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Concrete, a versatile construction material, faces pervasive deterioration due to microbiologically influenced corrosion (MIC) in various applications, including sewer systems, marine engineering, and buildings. MIC is initiated by microbial activities such as involving sulfate-reducing bacteria (SRB), sulfur-oxidizing bacteria (SOB), etc., producing corrosive substances like sulfuric acid.

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Article Synopsis
  • - GLP-1 receptor agonists are effective in treating obesity and type 2 diabetes, but their ability to reverse liver fibrosis in metabolic dysfunction-associated steatohepatitis (MASH) is still uncertain; survivodutide, a dual agonist targeting both glucagon and GLP-1 receptors, shows promise in addressing these issues.
  • - This review analyzes the pharmacology, effectiveness, and safety of survodutide based on results from initial clinical trials, highlighting its potential benefits over traditional GLP-1 receptor agonists.
  • - Expert opinions suggest that survodutide’s dual action may improve outcomes for MASH patients, offering manageable side effects and a more comprehensive treatment strategy as it moves toward phase
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