Effect of alaptide, its analogues and oxiracetam on memory for an elevated plus-maze in mice.

In the present study, the elevated plus-maze was used to evaluate memory in female mice. In Experiment 1, the mice retested on day 1, 4 or 7 after the initial session escaped from the open arm into the enclosed arm in a significantly shorter time than those retested on day 10 or 14. Thus, a 10-day inter-session interval was chosen for testing drugs which were expected to enhance memory.

The immunomodulatory properties of low-molecular tri- and tetrapeptides.

Immunomodulatory effects of six linear tri- or tetrapeptides were studied. These peptides are physiologically inert precursors, which under the action of native proteases split into a C-terminal dipeptide ester, which is subsequently converted by spontaneous intramolecular cyclization to a biologically active compound, i.e.

[The lateralized effects of the melanostatin analog alaptide in rats raised in isolation and in a community].

Effects of alaptide on self-stimulation of the lateral hypothalamus, rotation behaviour and learning ability were studied in rats growing either in social adaptation or in groups. The effects on self-stimulation were opposite in these rats. Alaptide facilitated the learning process in grouped rats and potentiated the indirect dophamine-mimetic action of amphetamine in isolated rats.

An analog of MIF, alaptide: effect on serum prolactin, dopamine receptors and growth of rat adenohypophysis.

Alaptide is a drug chemically derived from prolyl-leucyl-glycin amide (PLG) which is effective after oral administration. We studied the effect of long term treatment with alaptide and estradiol-benzoate on serum prolactin, growth reactivity and dopamine DA-2 receptors in the anterior pituitary of male rats. Alaptide reduced adenohypophyseal weight when given alone, but only nonsignificantly reduced growth reactivity of the anterior pituitary (AP) raised by estradiol-benzoate (EB).