Medications for Opioid Use Disorder Among Transition Age Youth Compared to Adults 26 or Older in Rural Settings.

Objective: Transition age youth (TAY), aged 18 to 25 years, face barriers to medication treatment for opioid use disorder (MOUD), resulting in lower retention. We evaluated OUD prevalence and MOUD receipt comparing TAY to adults aged 26 or older residing in rural settings.

Method: Electronic health records (October 2019 to January 2021) for 36,762 patients across 6 primary care clinics involved in a large feasibility trial in US rural communities were analyzed.

Deep and dynamic metabolic and structural imaging in living tissues.

Label-free imaging through two-photon autofluorescence of NAD(P)H allows for nondestructive, high-resolution visualization of cellular activities in living systems. However, its application to thick tissues has been restricted by its limited penetration depth within 300 μm, largely due to light scattering. Here, we demonstrate that the imaging depth for NAD(P)H can be extended to more than 700 μm in living engineered human multicellular microtissues by adopting multimode fiber-based, low repetition rate, high peak power, three-photon excitation of NAD(P)H at 1100 nm.

A theoretical investigation on the OER and ORR activity of graphene-based TM-N and TM-NX (X = B, C, O, P) single atom catalysts by density functional theory calculations.

Single-atom catalysts (SACs) have shown promising activity in electrocatalysis, such as CO reduction (CORR), the oxygen evolution reaction (OER) and the oxygen reduction reaction (ORR). Transition-metal-embedded N-doped graphene (M-N-C) with TM-N active sites (where TM represents a transition metal) is a representative SAC family that has attracted the most attention in both experimental and theoretical studies. However, TM-N type M-N-C has received less attention than TM-N, although some experimental studies have reported its excellent activity in OER and CORR.

Optimized Carbon Coupling for Enhanced Ethylene Production via a Unique Single-Atom-Substrate Synergy Mechanism within Photocatalytic Processes.

The utilization of solar-driven technologies for the direct conversion of methanol (CHOH) into two or multi-carbon compounds through controlled carbon-carbon (C-C) coupling is an appealing yet challenging objective. In this study, we successfully demonstrate the photocatalytic CHOH coupling to ethylene (CH), a valuable chemical raw material, by employing a carbon nitride-based catalyst. Specifically, we modify the layered polymer carbon nitride (PCN) photocatalyst through the incorporation of Au single atoms (Au/PCN) using a chemical-scissors method.