Publications by authors named "E Kampouri"
Off-the-shelf allogeneic natural killer cells for the treatment of COVID-19.
Mol Ther Methods Clin Dev
December 2024
Low levels and function of natural killer (NK) cells are associated with increased coronavirus disease 2019 (COVID-19) severity. NK cell immunotherapy may improve immune function to reduce infection severity. We conducted a first-in-human, open-label, phase 1, dose-escalating (100 × 10, 300 × 10, or 900 × 10 cells) study of a single dose of DVX201, a cord-blood-derived allogeneic NK cell therapy, in hospitalized patients with COVID-19.
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- Infections, especially from viruses, are a major cause of problems after CAR-T-cell therapy, which is a type of cancer treatment.
- Herpes viruses are common right after treatment, and while some are rare now due to medicine, the cytomegalovirus (CMV) can still be a serious issue for some patients.
- To help protect patients from these infections, better vaccination timing and types need to be researched, as vaccines may not work as well after the treatment.
Objectives: We aimed to determine the prevalence of HIV-related stigma among people with HIV (PWH) in Switzerland.
Design: A cross-sectional multicenter study nested within the Swiss HIV Cohort Study (SHCS).
Methods: We included adult PWH enrolled in the SHCS, attending follow-up between March 1, 2020, and January 31, 2021.
Article Synopsis
- Cytomegalovirus (CMV) disease can occur before hematopoietic cell transplantation (HCT) and negatively affect post-transplant outcomes, but the effects of reactivation prior to the procedure were previously unclear.
- A study found that 11% of HCT candidates experienced pre-HCT CMV reactivation, with lymphopenia identified as a strong risk factor.
- The presence of pre-HCT CMV reactivation was linked to higher risks of further reactivation and related diseases within the first year after HCT, supporting the need for regular surveillance and potential antiviral therapy in high-risk patients.