Comparative pharmacokinetics of 14C-piperacillin following intravenous and intraperitoneal administration in pregnant and non-pregnant rats.

14C-piperacillin (Pipracil) at a dose level of 1000 mg/kg was administered intravenously or intraperitoneally to pregnant and non-pregnant female rats. Rats were sacrificed at predetermined time intervals, and 14C-piperacillin concentrations determined in serum, amniotic fluid, placenta, and fetus. The piperacillin serum levels in both pregnant and nonpregnant rats following intravenous administration were comparable; however, following intraperitoneal administration, the serum drug levels in the pregnant rats as compared to the nonpregnant rats were lower.

Tissue distribution of [14C]ethambutol in mice.

Fifteen male mice were given oral doses of 32 mg [14C]ethambutol/kg in a study of the tissue distribution of the drug. Animals were killed 1, 2, 4, 7, and 24 h after dosage and radioactivity in various tissues was measured. Peak concentrations were seen at 2 h after dosage.