Publications by authors named "E Kaklamani"
Behçet's disease (BD) is widely known to be strongly associated with human leukocyte antigen (HLA) B51 in many different ethnic groups.Recently, HLA-B51 allele typing of Greek BD patients was performed to study the distribution of B*5101-B*5107 alleles in this Greek population, the B51 antigen strongly associated with BD was found to be predominantly encoded by allele B*5101. As it is now known that the B51 antigen can be encoded by 21 alleles, B*5101-B*5121, we performed HLA-B*51 allele genotyping among 58 Greek patients with BD.
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- Understanding the genetic basis of autoimmune diseases is still limited, and cytokine gene polymorphisms may help explain variations in immune responses and susceptibility to diseases.
- The study focused on the IL-12 gene, specifically a polymorphic region identified in its 3' untranslated region, which showed significant variation among different population groups.
- In cases studied, the identified polymorphism was not linked to major autoimmune diseases like rheumatoid arthritis or multiple sclerosis but showed a potential association with a less common syndrome, suggesting further research is needed in broader contexts.
Localization of the pathogenic gene of Behçet's disease by microsatellite analysis of three different populations.
Invest Ophthalmol Vis Sci
November 2000
Purpose: Behçet's disease (BD) is known to be associated with HLA-B51 in many ethnic groups. However, the pathogenic gene responsible for BD is as yet unknown. To localize the critical region of the pathogenic gene, microsatellite markers distributed around the HLA-B gene were investigated.
View Article and Find Full Text PDFThe serum levels of several cytokines were determined in 94 patients with Adamantiades-Behçet's disease (ABD), aged 36.1+/-11.0 years, during the active stage (n = 75) and the inactive stage (n = 19) of the disease.
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