Publications by authors named "E K Sadykov"
A series of small coinage metal(I) clusters has been selectively synthesized using 2-(diphenylphosphino)-1,10-phenanthroline (L), a new promising dimetal-binding -ligand (L). Its reaction with CuI yields the complex [CuL(μ-I)][CuI], while the treatment of L with Au(tht)Cl/Ag or Au(tht)Cl/Cu systems leads to the assembly of [AuAgLCl], [AuCuLCl], [CuAuL] and [AgAuL] clusters. Theoretical analysis revealed pronounced intermetallic close shell interactions in these di- and trinuclear ensembles.
View Article and Find Full Text PDFNovel copper-containing bionanocomposites based on the natural raw arabinogalactan have been obtained as universal effective agents against phytopathogen and development stimulants of agricultural plants. Thus, the use of such nanosystems offers a solution to the tasks set in biotechnology while maintaining high environmental standards using non-toxic, biocompatible, and biodegradable natural biopolymers. The physicochemical characteristics of nanocomposites were determined using a number of analytical methods (elemental analysis, transmission electron microscopy and spectroscopic parameters of electron paramagnetic resonance, UV-visible, etc.
View Article and Find Full Text PDFWe report here an unprecedentedly fast and reversible transformation between 1D and 2D MOFs/CPs induced through organic solvent vapours. The transformations occur at room temperature in just 15-20 min, accompanied by a significant change in the observed phosphorescence. These findings provide a new insight into the design of luminescent networks with stimuli-switchable dimensionality.
View Article and Find Full Text PDFObjectives: Studies of schizophrenia endophenotypes may help clinicians better understand the etiopathogenesis and treatment of this mental disorder. The aim of the study was to determine if retinal arteriolar or venular abnormalities are an endophenotype of schizophrenia.
Design: We performed a one-time cross-sectional study.
Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11-Indeno[1,2-]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime.
Pharmaceutics
June 2023
Article Synopsis
- 11-Indeno[1,2-]quinoxalin-11-one oxime and tryptanthrin-6-oxime are identified as effective inhibitors of the c-Jun N-terminal kinase 3 (JNK-3), which have neuroprotective and anti-inflammatory properties.
- The stereochemical configuration of the oxime carbon-nitrogen double bond in these compounds, previously unknown, was determined using single crystal X-ray diffraction and NMR techniques.
- Results indicate that both compounds have the -configuration in both solid state and solution, stabilized by intermolecular hydrogen bonds, opposing the earlier assumption of a -configuration reliant on intramolecular hydrogen bonds.