Publications by authors named "E K Roshchina"
Head and neck squamous cell carcinoma (HNSCC) ranks among the most prevalent global cancers. Despite advancements in treatments, the five-year survival rate remains at approximately 66%. The histone methyltransferase NSD1, known for its role in catalyzing histone H3 lysine 36 di-methylation (H3K36me), emerges as a potential oncogenic factor in HNSCC.
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- TNF-α is a cytokine involved in immune response and inflammation and is activated during influenza A virus infections, leading to increased production of other cytokines.
- Researchers created a knockout mouse strain lacking TNF-α, which showed more viral genomes but similar amounts of live virus compared to normal mice.
- The modified mice had less lung inflammation, suggesting this model can help further investigate the effects of viral infections on pathology.
Purpose: Metastatic involvement of the lingual lymph nodes (LLNs) in oral cavity squamous cell cancer (SCC) has recently been proven to significantly reduce locoregional control and survival. Despite recent refinements in the detection of these lesions, the understanding of the LLN topographic anatomy among clinicians is limited. A proposition of a topographic division on LLN based on a comprehensive literature search and synthesis may be helpful in this condition.
View Article and Find Full Text PDFBackground: Physio ring (SR) is considered an improved version of the Classic rigid ring (RR). Today, SR is more widely used in mitral valve (MV) repair. We sought to compare the long-term outcomes of repair with RR and SR in degenerative mitral valve disease.
View Article and Find Full Text PDFDetermination of native amino acids and lactic acid inLactobacillus helveticusculture media by capillary electrophoresis using Cuand β-cyclodextrins as additives.
J Chromatogr B Analyt Technol Biomed Life Sci
November 2020
Article Synopsis
- A new capillary electrophoresis method was developed for the selective detection and quantification of amino acids and lactic acid during the cultivation of Lactobacillus helveticus strains D75 and D76 using different nutrient media.
- The method utilizes sensitive UV detection and minimal sample preparation, separating the compounds as complexes with copper ions, while employing various forms of β-cyclodextrin for improved separation selectivity.
- The study found significant differences in amino acid production between the two strains, suggesting a synergistic relationship, and confirmed that the method is effective for analyzing culture media.