Publications by authors named "E K Pearman"
Coverage of community-wide mass drug administration platforms for soil-transmitted helminths in Benin, India, and Malawi: findings from the DeWorm3 project.
Arianna Rubin Means Kristjana Hrönn Ásbjörnsdóttir Katherine C Sharrock Sean R Galagan Kumudha Aruldas Emily Pearman
Infect Dis Poverty
October 2024
Background: Soil-transmitted helminths (STH) affect approximately 1.5 billion people globally. The current STH control strategy is annual or twice-annual preventive chemotherapy, typically school-based deworming targeting children and women of reproductive age.
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- School-based health services may inadvertently exclude children with disabilities, while community-based approaches provide a more inclusive option for addressing their needs.
- The study focuses on assessing disability prevalence among children aged 5-17 in Malawi and compares the effectiveness of school-based deworming (SBD) versus community-based deworming (CBD) for treating soil-transmitted helminths in these children.
- Findings show a 3.3% disability prevalence, mainly affecting hearing, remembering, and communication, with boys more likely to have disabilities, which corresponded with lower school attendance and poorer health outcomes.
Background: Soil-transmitted helminth infections (STH) are associated with substantial morbidity in low-and-middle-income countries, accounting for 2.7 million disability-adjusted life years annually. Current World Health Organization guidelines recommend controlling STH-associated morbidity through periodic deworming of at-risk populations, including children and women of reproductive age (15-49 years).
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- The study compares patient-reported outcomes (PROs) for localized prostate cancer at diagnosis across different countries, suggesting that treatment recommendations may vary despite similar patient profiles.
- The analysis included data from 13,483 men across seven regions, using EPIC-26 scores to evaluate differences before treatment based on various approaches like radical prostatectomy and radiotherapy.
- Findings showed significant variation in sexual health scores, while urinary incontinence and bowel domains had higher scores and were more consistent across regions, indicating overall good outcomes in these areas.
Article Synopsis
- Soil Transmitted Helminths (STH) infect over 1.5 billion people worldwide, leading to significant health issues like anemia and stunting, and causing around 1.9 million Disability-Adjusted Life Years (DALYs) lost annually.
- The DeWorm3 trial, conducted in Benin, India, and Malawi, aims to evaluate the effectiveness of community-wide mass drug administration (MDA) for STH, as opposed to the traditional school-based deworming (SBD) methods.
- Analysis of reporting from the DeWorm3 trial reveals that school-level SBD coverage is likely overestimated when compared to individual-level surveys, with actual coverage rates dropping significantly in all study sites after corrections for