Publications by authors named "E K Omori"
Hemorrhagic shock and resuscitation (HSR) enhances the risk of acute lung injury (ALI). This study investigated the protective effect of carbamazepine (CBZ) on HSR-induced ALI in rats. Male Sprague-Dawley rats were allocated into five distinct groups through randomization: control (SHAM), saline + HSR (HSR), CBZ + HSR (CBZ/HSR), dimethyl sulfoxide (DMSO) + HSR (DMSO/HSR), and CBZ + chloroquine (CQ) + HSR (CBZ/CQ/HSR).
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- Dexmedetomidine (DEX) helps reduce lung injury in rat models of hemorrhagic shock resuscitation by reducing inflammation.
- The study examined lung tissue to see if DEX's protective effects were linked to the activation of autophagy, an important cellular process.
- Results showed that DEX treatment led to changes in specific autophagy-related proteins, enhancing lung recovery, but this effect was negated when an autophagy inhibitor (chloroquine) was used.
Twist-coupled elastic deformations are ubiquitous and in the limelight of interest for next-generation self-shaping materials. Here, we describe how twist dynamics under fixed anchoring lead to bend deformation and defect dynamics in a field-unwound chiral liquid crystal material. We use the Q-tensor dynamics under the Landau-de Gennes formalism in a finite-element mesh to explore the texture pathways from the unwound (homeotropic) to the helical planar structure.
View Article and Find Full Text PDFThe heme component of myoglobin plays a crucial role in the pathogenesis of rhabdomyolysis-associated acute kidney injury (RM-AKI). Heme oxiganenase-1 (HO-1) is the rate-limiting enzyme of heme catabolism, and its metabolites, iron, biliverdin, and carbon monoxide, have antioxidant properties. Tin chloride (SnCl2) is a kidney specific HO-1 inducer.
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- Hepatic oxidative stress is linked to various acute liver diseases, with free heme contributing to liver injury caused by endotoxemia.
- In a study involving rats, LPS treatment increased HO-1 expression while decreasing ALAS1 expression, indicating a rise in hepatic free heme levels.
- Elevated heme also reduced nuclear levels of the transcription factor Bach1, suggesting a complex regulation where increased Bach1 mRNA might compensate for its decline in the nucleus after LPS exposure.