Publications by authors named "E K O'Shea"
Background: The optimal approach to the diagnosis of atrial fibrillation in primary care is unclear.
Aim: To determine if external loop recorder (ELR) screening improves atrial fibrillation detection in community dwelling adults with a CHA2DS2-VASc score of greater than two.
Design: Randomised cross-over clinical trial.
Background: Social prescribing link workers support patients to connect with community resources to improve their health and well-being. These roles are prominent in policy, but there is limited evidence on what support is provided by link workers and what factors influence implementation of link worker interventions.
Methods: A convergent, mixed methods process evaluation of an exploratory randomised trial of a one-month general practice-based link worker intervention targeting adults with multimorbidity in deprived areas.
Article Synopsis
- The study investigates the glycemic patterns in children with congenital hyperinsulinism (HI) using Continuous Glucose Monitoring (CGM) over a 12-month period to provide better insights for future treatments.
- It involved 45 patients, revealing a consistent risk of hypoglycemia, especially early in the morning, but showed that CGM did not effectively reduce these episodes and the device's accuracy was found to be poor.
- Despite high dissatisfaction among patients and families regarding CGM usage, qualitative feedback indicated that it helped them understand glycemic patterns and make behavior adjustments to reduce hypoglycemia.
The role of the oral microbiome in mental health has recently been appreciated within the proposed oral-brain axis. This study examined the structure and composition of the salivary microbiome in a large-scale population-based cohort of individuals reporting mental health symptoms (n = 306) compared to mentally healthy controls (n = 164) using 16S rRNA sequencing. Mental health symptoms were evaluated using validated questionnaires and included depression, anxiety, and posttraumatic stress disorder (PTSD), with accompanying periodontal outcomes.
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- AMPA-type receptors (AMPARs) enhance synaptic transmission during plasticity, but the mechanism of their selective trafficking to synapses is unclear.
- Research in cultured rat hippocampal neurons reveals that GluA1-containing vesicles are concentrated near areas of stimulated synaptic changes through confinement.
- This confinement is driven by actin polymerization, which limits the transport of these vesicles along dendrites while also promoting their movement to exocytic sites, thereby increasing their availability during synaptic activity.