Retrospective case-case study investigation of a significant increase in spp. in England and Wales, August to September 2023.

BackgroundLaboratory surveillance detected an unprecedented increase in spp. (predominantly ) in England and Wales in August 2023. Cases are not routinely followed up in all of England and Wales, and initial investigations identified no common exposures.

A case report of fracture-related infection with in an immunocompetent patient.

We report a case of post-traumatic fracture-related infection of the right femur in a young male with no identified immunodeficiency. Treatment required multiple washouts and femoral nail revision, combined with 10 weeks of treatment with doxycycline and clindamycin.

Novel Splice-Altering Variants in the and Genes Causative of X-Linked Choroideremia and Cone Dystrophy.

Background: An estimated 10-15% of all genetic diseases are attributable to variants in noncanonical splice sites, auxiliary splice sites and deep-intronic variants. Most of these unstudied variants are classified as variants of uncertain significance (VUS), which are not clinically actionable. This study investigated two novel splice-altering variants, NM_000390.

Affective and neural mechanisms of how identity dysfunction in borderline personality disorder may interfere with building positive relationships.

Individuals with borderline personality disorder (BPD) often hold pervasive and negative self-views and experience feelings of low connectedness toward others despite effective treatment. This study aimed to identify neural and affective mechanisms of identity disturbance in BPD that contribute to difficulties in relating to others. Participants diagnosed with BPD ( = 34) and nonclinical controls (NCC; = 35) completed a within-subject social feedback task inside a magnetic resonance imaging scanner.

RNA-programmable cell type monitoring and manipulation in the human cortex with CellREADR.

Reliable and systematic experimental access to diverse cell types is necessary for understanding the neural circuit organization, function, and pathophysiology of the human brain. Methods for targeting human neural populations are scarce and currently center around identifying and engineering transcriptional enhancers and viral capsids. Here we demonstrate the utility of CellREADR, a programmable RNA sensor-effector technology that couples cellular RNA sensing to effector protein translation, for accessing, monitoring, and manipulating specific neuron types in human cortical tissues.