Effect of XRCC1 Arg399Gln Gene Polymorphism on Survival in Lymphoblastic Leukemia.

Introduction: The relevance of the research of the article is conditioned upon the problem of the development of molecular genetic diagnostics to determine the effectiveness of treatment for acute lymphoblastic leukemia in children. The purpose of the article is to identify the polymorphism parameters of the P53 Arg72Pro and XRCC1 Arg399Gln genes in acute lymphoblastic leukemia with criteria for determining the survival rates of sick children.

Materials And Methods: Methods for the study of the identified problem are the study of the medical histories of children with acute leukemia, which allowed selection of the necessary contingent of patients for further genetic study of their frozen blood, where the genomic part of deoxyribonucleic acid was isolated from the frozen blood in a standard way using molecular biological research when performing a polymerase chain reaction.

Breast Cancer Incidence in Kyrgyzstan: Report of 15 Years of Cancer Registry.

Objective: The epidemiological features of the breast cancer (BC) incidence in Kyrgyzstan were studied.

Methods: The retrospective study (2003-2017). Descriptive and analytical methods of oncoepidemiology were used.

Global Retinoblastoma Presentation and Analysis by National Income Level.

Importance: Early diagnosis of retinoblastoma, the most common intraocular cancer, can save both a child's life and vision. However, anecdotal evidence suggests that many children across the world are diagnosed late. To our knowledge, the clinical presentation of retinoblastoma has never been assessed on a global scale.

[Use of immunoglobulin E and pregnancy-specific beta-1-glycoprotein in differential diagnosis of bone malignancies].

Such factors as high levels of immunoglobulin E and pregnancy-specific 1-glycoprotein (PSG) appear as diagnostic criteria for both bone malignancies and acute hematogenous osteomyelitis. It was found that significant increase in blood-serum PSG in conjunction with lowered IgE is a marker of bone malignancy while decreased PSG and high IgE is that of acute hematogenous osteomyelitis.