- Tobacco use is common in developing countries like India, leading to studies on genetic damage in smokers and smokeless tobacco users in rural Tamilnadu.
- Researchers assessed DNA damage through various tests including chromosome aberrations and micronucleus frequency on blood samples and buccal cells.
- Findings showed increased genetic damage in tobacco users, with 17% having a specific XRCC1 gene variant and 19% having a p53 gene variant, both linked to higher cancer risk.