[Zeta-potential of n-alkane emulsion droplets and its role in substrate transport into yeast cells].

Zeta-potential of n-alkane droplets, formed by fatty acids, were studied in model systems of culture liquid of yeasts (Candida maltosa) capable of utilizing n-alkanes. The value of zeta-potential was found to depend on the droplet size. The negative zeta-potential of submicron droplets was so high that it prevented the droplets from being coagulated with cells possessing a high negative zeta-potential.

[The characteristics of the hypothalamic monoaminergic regulation of adrenal cortical function in patients with hyperandrogenemia].

Since the majority of monoamines cannot penetrate through the hematoencephalic barrier, it is difficult to study their central metabolic disturbances. The ethymisole test was used to study the adrenocortical function in patients with hyperandrogenemia; ethymisole can penetrate through this barrier, it stimulates the brain structures that regulate adrenocortical function via endogenic monoamines activation. In 10 patients with the common form of ovarian polycystosis the ACTH and hydrocortisone response to ethymisole administration was virtually the same as in the reference group.

[Features of the adrenal cortex function in patients with hyperandrogenism of various etiology].

ACTH, prolactin, hydrocortisone, 17 OH-progesterone, androstenedione, dehydroepiandrosterone C, and testosterone were measured in the blood of 36 androgenic women and 8 healthy ones before and after adrenal stimulation. The findings evidence that various mechanisms are responsible for the development of androgynism of an adrenal origin. In patients with congenital virilizing adrenocortical hyperplasia and 21 hydroxylase deficiency excessive androgen production results mainly from activation of delta-4 route of androgen synthesis; in patients with adrenal androgynism and insufficiency of enzymic systems of steroidogenesis the androgen production is explained by functional hyperactivity of the bundle and retinal zones of the adrenal cortex and hyperreactivity to stimulating factors.

[The therapeutic effect of parlodel in the polycystic ovary syndrome].

Parlodel (2.5-50 mg/day) has been given for 1 to 7 days to 33 patients with the polycystic ovary syndrome (POS). The ovulatory menstrual cycle returned in 10 (30%) patients and 4 of them conceived.

[Specialized radiation-induced heritable nonstochastic damage at the cellular level of the organization].

In addition to widely known stochastic mutation effects, radiation also induces qualitatively different threshold (nonstochastic) changes that influence the genome but are not conditioned by mutations. The main characteristics of these changes are: spasmodic occurrence in virtually 100% of cells; independence of radiation dose (with regard to the degree of manifestation); low inducing doses; absence of repair throughout the indefinitely large number of cell generations; nonspecificity to mutagen agents, etc. The occurrence of the above changes among objects of different organization is demonstrated and the necessity of taking them into account in estimating a radiation danger is indicated.