[Bronchial hypersensitivity in children with the neutrophilic phenotype of bronchial asthma and GSTM1 and GSTT1 gene polymorphism].

Introduction: The relationship between bronchial hypersensitivity as the key phenomenon ofbronchial asthma and detoxication GSTM1 or GSTT1 gene polymorphism in children with neutrophilic phenotype of this disease remains unclear

Materials And Methods: 33 children with bronchial asthma of neutrophile phenotype were examined in histamine and dosed physical exercise (running) tests. In addition GSTM1 and GSTT1 genotyping was performed.

Results: Histamine test revealed bronchial hypersensitivity (HTC < 0.

[The assessment of the efficacy of calcium antagonists in the treatment of children with repeated episodes of the broncho-obstructive syndrome].

Overall seventy-five schoolchildren with a history of no less than 4 episodes of impassability commonly against the afebrile background were examined. The results obtained suggest that the greatest reduction in the relative risk of bronchial unspecific hyperreactivity manifestations with calcium antagonists being ingested occurs in those children experiencing recurrent episodes of bronchial obstruction in the presence of marked lability of the bronchi that is commonly associated with the atopic genesis of their obstruction.

[The anti-inflammatory activity of structural analogs of the platelet-activating factor].

The pro- and anti-inflammatory activity of new structural analogues of the platelet-activating factor (PAF) was studied. It was found that three PAF analogues inhibit PAF-induced rat paw edema in a dose-dependent manner. The anti-inflammatory activity of one of the PAF analogues upon PAF- or carrageenan-induced inflammation was comparable or in some extent exceeded that of dexamethasone.

[Study of rat liver mitochondrial proteins by two-dimensional electrophoresis].

About 50 protein fractions with molecular mass 15-158 kDa were detected in purified mitochondria isolated from rat liver homogenate after two-dimensional electrophoresis performed as described by O'Farrell. Individual spots, corresponding to proteins of inner mitochondrial membrane, disappeared from electrophoregrams as a result of incubation of the isolated mitochondria at 37 degrees and pH 7.5.