Problem: Immunotherapies [leukocyte immunization, intravenous immunoglobulin (IVIG)] introduced to treat women with recurrent spontaneous abortions (RSA) have still controversial results in most clinical trials. A selection of these patients would be advantageous for higher efficacy.
Method Of Study: A complex immunological panel assay was offered to patients with reproductive failure without any other known cause.
Introduction: Recurrent spontaneous abortion (RSA) is diagnosed if three or more spontaneous abortions follow each other typically in the first trimester. The root cause of miscarriages often can not be found. A significant proportion of this unexplained RSA cases may be caused by immunopathological failure.
View Article and Find Full Text PDFThe review paper summarizes the advantages of the living donor kidney transplantation aiming that this kind of activity should get more support in Hungary. It is a general phenomenon overall the world, that there is no more possibility to increase the number of cadaver transplantations, and the outcome of them is also worsening because of the accumulation of aged patients with long time period of dialysis treatment. The paper points out the better results of living donor kidney transplantation underlining that the kidney long term survival, in general, is 10% over the cadaver kidney survival with significant less complication.
View Article and Find Full Text PDFStudies of human population genetics in Hungary have revealed relevant heterogeneity in the major histocompatibility complex. In the present studies, two isolated ethnic groups were chosen: people living in the Káli Basin westward from the Danube River, and those living in Opusztaszer, a village eastward from Danube, who are known as native ancient Hungarians. Blood samples were collected from 70 people in the Káli Basin and from 45 people in Opusztaszer.
View Article and Find Full Text PDFChimerism is an exceptional immunogenetic state, characterized by the survival and collaboration of cell populations originated from two different individuals. The prerequisites to induce chimerism are immunosuppression, myeloablation or severe immunodeficiency of the recipients on one side and donor originated immuno-hematopoietic cells in the graft on the other. Special immunogenetic conditions to establish chimerism are combined with bone marrow transplantation, transfusion and various kinds of solid organ grafting.
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