Developing Topics.

Background: Therapeutic monoclonal antibodies targeting amyloid beta-protein (Ab), such as lecanemab, represent a promising approach for disease-modification in Alzheimer's disease (AD). Due to its relatively short half-life, lecanemab is given as a bi-monthly infusion (typically 10mg/kg). Binding to high abundance plasma proteins (PPB) can influence the pharmacokinetics of drugs in the blood, including their half-life.

RapA opens the RNA polymerase clamp to disrupt post-termination complexes and prevent cytotoxic R-loop formation.

Following transcript release during intrinsic termination, Escherichia coli RNA polymerase (RNAP) often remains associated with DNA in a post-termination complex (PTC). RNAPs in PTCs are removed from the DNA by the SWI2/SNF2 adenosine triphosphatase (ATPase) RapA. Here we determined PTC structures on negatively supercoiled DNA and with RapA engaged to dislodge the PTC.

Changes in traffic-related air pollution exposures and associations with adverse birth outcomes over 20 years in Texas.

Background: Billions of dollars have been spent implementing regulations to reduce traffic-related air pollution (TRAP) from exhaust pipe emissions. However, few health studies have evaluated the change in TRAP emissions and associations with infant health outcomes. We hypothesize that the magnitude of association between vehicle exposure measures and adverse birth outcomes has decreased over time, parallelling regulatory improvements in exhaust pipe emissions.

EMG-based wake gestures eliminate false activations during out-of-set activities of daily living: An online myoelectric control study.

Objective: While myoelectric control has been commercialized in prosthetics for decades, its adoption for more general human-machine interaction has been slow. Although high accuracies can be achieved across many gestures, current control approaches are prone to false activations in real-world conditions. This is because the same electromyogram (EMG) signals generated during the elicitation of gestures are also naturally activated when performing activities of daily living (ADLs), such as when driving to work or while typing on a keyboard.